Israeli inventor of promising COVID drug hopes it can help vaccineless countries
The inventor of a new Israeli coronavirus medicine has secured the prime minister’s help to advance testing — and says the drug could provide hope to poor countries that don’t yet have access to vaccines.Israeli COVID cure? Researchers hope peptide treatment could slow disease
Tel Aviv’s Ichilov Medical Center claimed a “huge breakthrough” on Friday, saying that Prof. Nadir Arber’s EXO-CD24 inhaled medicine had been administered to 30 patients whose conditions were moderate or worse, and all 30 recovered — 29 of them within three to five days.
On Monday, Prime Minister Benjamin Netanyahu invited Arber to his office and asked him about the “miracle drug.” During the briefing, Netanyahu said: “If this succeeds, it will be huge, simply huge. This is of global significance. This is amazing.
“I wish you success. If you need anything, say it and we will help you. This little thing could change the fate of humanity. This is amazing. Good luck.”
Arber told The Times of Israel on Tuesday that, with the Phase 1 trial just completed, he has applied to the Health Ministry to start a Phase 2 trial. This will give a more reliable picture of efficacy, as Phase 1 is small, largely concerned with checking safety, and lacking a placebo group.
Netanyahu has already helped to pave the way to a multi-country trial. After meeting with Arber, he hosted Greek Prime Minister Kyriakos Mitsotakis, who offered to have a leading Greek hospital take part in testing in the framework of bilateral cooperation.
“I asked Professor Arber to come to my office today. He did. Two hours later my friend Prime Minister Mitsotakis comes to my office and more or less the first question he asked me was, ‘Can you tell me about this miracle drug?'” said Netanyahu.
“We called Professor Arber and Prime Minister Mitsotakis volunteered that Greece, their leading hospital, would partake in the clinical trials and I hope that we can approve this because I think this is an example of our cooperation in forging ahead to new areas.”
A group of Israeli researchers have launched a Phase II study of a drug that they believe could keep patients off mechanical ventilation and speed their recovery.‘Palestinians deserve better’
The trial, which is being collectively run by Ziv and Rambam medical centers with researchers from Bar-Ilan University and Technion-Israel Institute of Technology, is examining the use of a drug based on a naturally occurring peptide called angiotensin 1-7 to help counter the impact of COVID-19 on the lungs.
A peptide is a set of amino acids.
Coronavirus enters a person’s cells through angiotensin-converting enzyme 2 (ACE2) receptors. These same receptors produce angiotensin 1-7, explained Dr. Karl Skorecki, dean of the Azrieli Faculty of Medicine of Bar-Ilan University in the Galilee. Angiotensin 1-7 is a protein that is naturally produced in the body and is responsible for preventing cell proliferation and inflammation.
“When the enzyme is busy acting as a receptor, it can no longer do what it is supposed to do, which is make angiotensin 1-7,” Skorecki said. “The hope is that by replenishing this peptide, their lungs will get back what the virus nefariously took away from them.”
Around 3% of all people who contract coronavirus in Israel are hospitalized, and many do not respond to what have become traditional steroid or antiviral drug treatments.
Sir, – The Palestinian people deserve better (Jilan Wahba Abdalmajid, “Israel’s obligations as an occupying power under the Geneva Convention still stand”, Opinion & Analysis, February 4th).
They deserve leaders who truly care about their people, and not those who consider Palestinian people as pawns to be used in endless political posturing. Under the Oslo Accords, which are the existing applicable legal framework between Israel and the Palestinians, all civic powers and responsibilities – including in the sphere of health – in the West Bank and Gaza are under the mandate of the Palestinians. This includes responsibility for the administration of vaccinations to the Palestinian population.
In the past year, governments around the world have taken decisive measures to protect their populations from the ravages of the Covid-19 pandemic. These measures have had tremendous societal and economic impacts but were taken with the understanding that there was simply no other choice. In Israel, like other places around the world, the welfare and health of citizens is the first priority. Israel devoted huge efforts and resources into finding ways to fight the pandemic. Israeli scientists, engineers and entrepreneurs pioneered innovative ways to deal with various aspects of Covid-19, including the development of an Israeli vaccine (now in trial phases), development of a cure for the disease (also in trials), and more. Securing early vaccination of the entire population became the top priority of the Israeli government, who managed to secure that by swift negotiation of agreements with major suppliers, in particular Pfizer. Israel became a world leader in vaccinating its population while providing real-time data about the effectiveness of the vaccines to the rest of the world.
Meanwhile, in a politically motivated galaxy far far away, Palestinian leaders, and some of their supporters, have been engaged in weaponising the pandemic against Israel and hijacking the Covid agenda for their narrow political goal. OPHIR KARIV, Ambassador of Israel to Ireland