PizzaIDF - will deliver Mishloach Manot to IDF soldiers
Yad Ezra VeShulamit - delivers food to the poor in Israel; has Matanot Le'Evyonim program
Yad Eliezer - also delivers food baskets in Israel; last year gave out $220,000 on Purim day
Ezras Yisroel - gives to the needy in the US
Carmel Ha'ir - soup kitchen in Jerusalem
Ezrat Avot - provides support for the elderly poor in Jerusalem
Hazon Yeshaya - provides soup kitchens in Eilat and (soon) Ashkelon
Lema'an Achai - Comprehensive solutions for poor people in Israel
Eizer L'Shabbos - help for Jews of Tzfat; recommended by A Simple Jew
If you have any other charities that have specific Purim programs, let me know and I will add the information.
Purim will be celebrated this coming Sunday (Monday in Jerusalem.)
